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Haldol/Diphenhydramine Versus Metoclopramide/Diphenhydramine for Treatment of Acute Headache in the ED: A RCT

NCT02098499 · Status: WITHDRAWN · Phase: PHASE4 · Type: INTERVENTIONAL

Last updated 2025-07-29

No results posted yet for this study

Summary

Haloperidol is known to be a safe alternative medication to control difficult pain, and has been shown effective when compared to placebo for controlling headaches. Investigators hypothesized that the combination of haloperidol and diphenhydramine would be a useful medication choice for migraine headache patients in the emergency department in comparison to a common migraine treatment regimen of metoclopramide and diphenhydramine.

Conditions

  • Migraine Headaches
  • Nausea
  • Restlessness

Interventions

DRUG

Haloperidol

5mg IV

DRUG

Metoclopramide 10mg

10mg IV

DRUG

Diphenhydramine

25mg IV

Sponsors & Collaborators

  • United States Naval Medical Center, Portsmouth

    lead FED

Principal Investigators

  • Matthew Gaffigan, MD · United States Naval Medical Center, Portsmouth

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-06-12
Primary Completion
2015-02-11
Completion
2015-02-11

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02098499 on ClinicalTrials.gov