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Comparison of Ondansetron, Metoclopramide and Promethazine for the Treatment of Nausea and Vomiting in the Adult ED

NCT00655642 · Status: TERMINATED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 171

Last updated 2013-10-30

Study results available
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Summary

The purpose of this study is to compare the effectiveness of ondansetron, metoclopramide, and promethazine for the treatment of nausea in the adult emergency department population.

We hypothesize that a single intravenous dose of ondansetron is more effective in reducing nausea than a single IV dose of metoclopramide, promethazine or normal saline placebo in undifferentiated adult emergency department patients.

Conditions

Interventions

DRUG

Ondansetron

4 mg intravenous dose administered over 2 minutes through a peripheral intravenous catheter

DRUG

Metoclopramide

10 mg intravenous dose administered over 2 minutes through a peripheral intravenous catheter

DRUG

Promethazine

12.5 mg intravenous dose administered over 2 minutes through a peripheral intravenous catheter

DRUG

Normal Saline

Volume matched isotonic sodium chloride solution dose administered over 2 minutes through a peripheral intravenous catheter

Sponsors & Collaborators

  • Vanderbilt University

    lead OTHER

Principal Investigators

  • Tyler W Barrett, MD · Vanderbilt University Medical Center

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2007-03-31
Primary Completion
2008-10-31
Completion
2008-10-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00655642 on ClinicalTrials.gov