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The Role of Dopaminergic and Glutamatergic Neurotransmission for Dysfunctional Learning in Alcohol Use Disorders

NCT02094196 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 60

Last updated 2020-07-30

No results posted yet for this study

Summary

The aim of this project is to assess reward- based learning behavior and its association with alterations in dopaminergic and glutamatergic transmission in detoxified alcohol-dependent patients and matched controls.

The investigators will explore how these alterations interact with clinical and psychosocial factors which can modify the relapse risk and learning deficits.

Patients will be detoxified in an inpatient setting. Clinical assessments, behavioral paradigms of learning and brain imaging will be carried out within at least 4 half- lives after any psychotropic medication.

The investigators will implement and apply functional imaging paradigms assessing Pavlovian-to-instrumental transfer and reversal learning tasks and associate model parameters of learning with alcohol craving, intake and prospective relapse risk.

In this project, the impact of the dopamine x glutamate interaction on learning deficits and consecutive relapse probability is targeted with \[18F\]fallypride PET and the measurement of absolute concentrations of glutamate with magnetic resonance spectroscopy (MRS).

Conditions

Interventions

OTHER

Alcohol detoxification

Detoxified alcohol- dependent patients in an inpatient setting

Sponsors & Collaborators

  • Charite University, Berlin, Germany

    collaborator OTHER

  • Technische Universität Dresden

    lead OTHER

Principal Investigators

  • Jürgen Gallinat, Prof MD · Charite University, Berlin, Germany

  • Andreas Heinz, Prof MD · Charite University, Berlin, Germany

  • Hans-Ulrich Wittchen, Prof PhD · Technische Universität Dresden, Dresden, Germany

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2012-12-31
Primary Completion
2018-04-30
Completion
2018-12-31

Countries

  • Germany

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02094196 on ClinicalTrials.gov