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Learning and Relapse Risk in Alcohol Dependence

NCT01679145 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 225

Last updated 2016-07-28

No results posted yet for this study

Summary

The aim of this project is to assess which behavioral and neuroimaging alterations associated with reward- based learning predict relapse in alcohol- dependent patients within a follow- up period of 12 months.

The investigators will explore how these alterations interact with clinical and psychosocial factors which can modify the relapse risk. Functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) will be used to identify neurofunctional abnormalities in neurotransmitter systems. The investigators will also provide data for genetic analysis and modeling.

Patients will be detoxified in an inpatient setting and followed for 12 months using the Time-Line Follow- Back Procedure. Clinical assessments, behavioral paradigms of learning and brain imaging will be carried out within at least 4 half- lives after any psychotropic medication.

The investigators will implement and apply functional imaging paradigms assessing Pavlovian-to-instrumental transfer and reversal learning tasks and associate model parameters of learning with alcohol craving, intake and prospective relapse risk.

Conditions

  • Alcohol Use Disorders

Sponsors & Collaborators

  • Charite University, Berlin, Germany

    collaborator OTHER

  • University Hospital Carl Gustav Carus

    collaborator OTHER

  • Technische Universität Dresden

    lead OTHER

Principal Investigators

  • Andreas Heinz, Prof MD · Charite University, Berlin, Germany

  • Ulrich S Zimmermann, MD · University Hospital Carl Gustav Carus, Dresden, Germany

  • Andreas Heinz, Prof MD · Charité University, Berlin, Germany

  • Hans-Ulrich Wittchen, Prof PhD · Technische Universität Dresden, Dresden, Germany

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2012-01-31
Primary Completion
2016-03-31
Completion
2016-03-31

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01679145 on ClinicalTrials.gov