MedTrace Logo

Predictive Biomarkers For Pediatric Chronic Graft-Versus-Host Disease

NCT02067832 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 302

Last updated 2023-12-05

No results posted yet for this study

Summary

Chronic graft-versus-host disease (cGVHD) can be hard to diagnose, difficult to manage and contributes significantly to morbidity and mortality in hematopoietic stem cell transplantation patients.

The research will look into identifying and validating cGVHD biological indicators (=bio-markers) which will be evaluated whether they can predict a future development of the disease.

The study hypothesis is that a number of previously reported cGVHD bio-markers, known to be present at the time of cGVHD diagnosis, will also be present at earlier time points, before cGVHD develops.

Following validation, the bio-markers will be beneficial for finding those patients who are in higher risk to develop cGVHD.

By identifying the higher-risk group, which is more likely to develop cGVHD, a pre-emptive therapy might be applied in order to prevent or reduce the prevalence of the disease.

Conditions

  • Chronic Graft vs Host Disease

Sponsors & Collaborators

  • University of British Columbia

    lead OTHER

Principal Investigators

  • Geoff Cuvelier, MD · University of Manitoba

  • Kirk R Schultz, MD · University of British Columbia

Eligibility

Max Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-11-30
Primary Completion
2024-12-31
Completion
2025-12-31

Countries

  • United States
  • Austria
  • Canada

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02067832 on ClinicalTrials.gov