Active Bathing to Eliminate Infection (ABATE Infection) Trial

Summary

The ABATE Infection Project is a cluster randomized trial of hospitals to compare two quality improvement strategies to reduce multi-drug resistant organisms and healthcare-associated infections in non-critical care units. The two strategies to be evaluated are:

* Arm 1: Routine Care Routine policy for showering/bathing
* Arm 2: Decolonization Use of chlorhexidine as routine soap for showering or bed bathing for all patients Mupirocin x 5 days if MRSA+ by history, culture, or screen

Note that enrolled "subjects" represents 53 individual HCA Hospitals (representing \~190 non-critical care units) that have been randomized.

Conditions

• Healthcare Associated Infections
• Methicillin Resistant Staphylococcus Aureus
• Multi Drug Resistant Organisms

Interventions

DRUG

Arm 2: Decolonization

Daily chlorhexidine (CHG) shower or CHG cloth bath for all non-critical care patients. Topical intranasal mupirocin ointment (bilateral nares, twice daily) x5 days if non-critical care patients are MRSA+ by history, culture, or screen.

Sponsors & Collaborators

• Harvard Medical School (HMS and HSDM)

  collaborator OTHER

• Harvard Pilgrim Health Care

  collaborator OTHER

• Hospital Corporation of America

  collaborator INDUSTRY

• Rush University

  collaborator OTHER

• Cook County Health

  collaborator OTHER_GOV

• Centers for Disease Control and Prevention

  collaborator FED

• National Institutes of Health (NIH)

  collaborator NIH

• National Institute of Allergy and Infectious Diseases (NIAID)

  collaborator NIH

• University of California, Irvine

  lead OTHER

Principal Investigators

• Susan Huang, MD MPH · University of California, Irvine

• Ken Kleinman, ScD · University of Massachusetts, Amherst

• Edward Septimus, MD · Hospital Corporation of America

• Jason Hickok, MBA, RN · Hospital Corporation of America

• Julia Moody, MS · Hospital Corporation of America

• Mary Hayden, MD · Rush University

• Robert Weinstein, MD · John Stroger Hospital

• John Jernigan, MD MS · Centers for Disease Control and Prevention

• Jonathan Perlin, MD PhD · Hospital Corporation of America

• Daniel Gillen, PhD · University of California, Irvine

• Grace Lee, MD MPH · Harvard Pilgrim Health Care Institute

Study Design

Allocation

RANDOMIZED

Purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

12 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2014-04-30

Primary Completion

2019-02-28

Completion

2019-02-28

Countries

• United States

Study Locations