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Ketamine and Changes of the Short Portable Mental Status Questionnaire

NCT02049411 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 80

Last updated 2014-11-25

No results posted yet for this study

Summary

\- Cognitive changes are related to aging, affecting the performance of older patients in the solution of problems and the execution of tasks.

This phenomenon has been observed as a decline of neurophysiological domains, especially memory, and the velocity of thought.

* Anesthesia and surgery performed contributes to its development then, is named post-operative cognitive dysfunction (POCD). The incidence varies due to conditions of:

1. Anesthesia and surgery.
2. The time elapsed after surgery.
3. The population studied, and the type of cognitive test employed.
* The aim of this study is to evaluate the changes around the Short Portable Mental Status Questionnaire (SPMSQ-E) after ketamine administration on ophthalmic surgery on the common conditions of geriatric patients, -comorbid and settings as minor surgery-.

Conditions

  • Postoperative Cognitive Dysfunction

Interventions

DRUG

Ketamine

Ketamine: (dose 0.3 mcg/kg) included in physiological solution at 0.9% (250 ml) during 2 hours, intravenously.

DRUG

physiological solution

physiological solution at 0.9% (250 ml) during 2 hours, intravenously, with the same physical characteristics of ketamine.

Sponsors & Collaborators

  • National Polytechnic Institute, Mexico

    collaborator OTHER

  • Instituto Mexicano del Seguro Social

    lead OTHER_GOV

Principal Investigators

  • Dulce M. Rascon, M.D · Instituto Mexicano del Seguro Social

  • Maria E. Ocharan, PhD. · Instituto Politecnico Nacional

  • Ana Fresan, PhD. · Instituto Nacional de Psiquiatria

  • Jorge H. Genis, Geriatrician · Instituto Mexicano del Seguro Social

  • Antonio Castellanos, M.D. · Instituto Mexicano del Seguro Social

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
60 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-06-30
Primary Completion
2014-01-31
Completion
2014-05-31

Countries

  • Mexico

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02049411 on ClinicalTrials.gov