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Neutrophil Gelatinase Associated Lipocalin (NGAL) in Urine: Can This Prove to be a Biomarker for Acute Kidney Injury in Patients With Sepsis?

NCT02034240 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 21

Last updated 2015-04-21

No results posted yet for this study

Summary

Patients with severe infection and sepsis are in high risk of hypo perfusion and therefore organ affection. Temporary or permanent kidney failure is a common complication in these patients. Today's golden standard for kidney failure detection is creatinine levels rising and / or oliguria. The investigators hypothesize that an even more sensitive biomarker; neutrophil gelatinase associated lipocalin(NGAL) in urine can predict kidney injury before creatinine levels rise. In recent studies NGAL in urine seem to be a sensitive biomarker in these patient to predict kidney injury, but the time factor for sampling optimally is not known. In this pilot study the investigators sample the urine at admission within the first hour of hospitalization to investigate if NGAL can be used as a predictor in an emergency setting.

Conditions

Sponsors & Collaborators

  • Kolding Sygehus

    collaborator OTHER

  • Sygehus Lillebaelt

    lead OTHER

Principal Investigators

  • Jannie Bisgaard Stæhr, PhD, M.D · Odense University Hospital

  • Claes Falkenberg Elvander, M.D · Kolding Sygehus

  • Srishamanthi Sriskandarajah, M.D · Kolding Sygehus

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-01-31
Primary Completion
2015-04-30
Completion
2015-04-30

Countries

  • Denmark

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02034240 on ClinicalTrials.gov