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Beta-lactam Pharmacokinetics in Patients With Infective Endocarditis

NCT02033421 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 40

Last updated 2015-06-18

No results posted yet for this study

Summary

The recommended length of antibiotic treatment to patients with infective endocarditis is 4-6 weeks. All patients receive the same dosis except for those with renal impairment who receive a smaller dose. For Beta-lactam antibiotics, a plasma concentration above the minimal inhibitory concentration (MIC) for at least 50% of the time in a dosing interval maximize bactericidal activity. To estimate the time for which the antibiotic concentration is above the MIC (T\>MIC) and to see if there might be a relationship between the concentration of antibiotics and possible side-effects, toxicity and treatment failure, all patients admitted with infective endocarditis will be followed and have two blood tests withdrawn once a week during antibiotic treatment, an expected average of 5 weeks.

Conditions

  • Infective Endocarditis

Sponsors & Collaborators

  • University of Aarhus

    lead OTHER

Principal Investigators

  • Henrik Wiggers, Md, D.Sc · Department of cardiology, Aarhus University hospital, Denmark

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-12-31
Primary Completion
2015-11-30
Completion
2016-01-31

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02033421 on ClinicalTrials.gov