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Effect of Carnosine on Diabetes and Cardiovascular Risk Factors

NCT02011100 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 28

Last updated 2018-04-17

No results posted yet for this study

Summary

Carnosine is a naturally occurring compound with a potential health benefits. In animal studies, carnosine supplementation reduces manifestation of chronic civilization diseases, regulates subclinical inflammation, protein glycation and lipid \& glucose metabolism. Our preliminary data showed the relationship between insulin resistance and carnosine content in human skeletal muscle. Based on these unique results we plan to perform intervention study aimed at identifying effects of carnosine on insulin sensitivity and secretion, which might reduce the development of T2D in obese. Similar metabolic effects of vitamin D3 were associated with expression of specific miRNAs. Circulating miRNAs related to carnosine action are unknown. The putative positive effects of carnosine on insulin sensitivity and secretion in obese patients might have a tremendous impact in prevention of type 2 diabetes. Identification of miRNAs associated with carnosine action could provide predictors of successful therapy.

Conditions

  • Metabolic Diseases, Type 2 Diabetes, Cardiovascular Disease

Interventions

DIETARY_SUPPLEMENT

Carnosine

Sponsors & Collaborators

  • Jozef Ukropec

    lead OTHER_GOV

Principal Investigators

  • Jozef Ukropec, PhD · Institute of experimental endocrinology SAS

  • Barbara Ukropcova, MD, PhD · Faculty of Medicine Comenius University & Institute of Experimental Endocrinology SAS

  • Boris Krahulec, MD, PhD · University Hospital in Bratislava

  • Barbora deCourten, MD, MPH, PhD, FRACP · Monash University

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
25 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-12-31
Primary Completion
2017-12-31
Completion
2018-03-31

Countries

  • Slovakia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02011100 on ClinicalTrials.gov