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Alternate Chemotherapy Regimens for the Clearance of W.Bancrofti Infection

NCT02005653 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 146

Last updated 2013-12-09

No results posted yet for this study

Summary

Diethylcarbamazine (DEC) essentially a micro-filaricidal drug is given for 12 days as standard treatment for the clearance of W. bancrofti infection. It takes about one year for the individuals to completely clear the microfilaria from the blood. It takes another two to four years to clear the antigen. The aim of the present study is to shorten the time taken for clearing the Mf and antigen from the blood either by co-administration or sequential administration of a macrofilaricidal drug, Albendazole or doxycycline. This study is a randomized, double blind, controlled clinical trial to study the efficacy of these drug combinations in complete clearance the Mf and antigen from the blood in shorter span of 180 days and 365 days respectively.

Conditions

  • Filarial; Infestation

Interventions

DRUG

Diethylcarbamazine

Diethylcarbamazine 300 mg tablet as single dose per day for 12 days

DRUG

Albendazole

Experimental

DRUG

Doxycycline

Experimental

Sponsors & Collaborators

  • Indian Council of Medical Research

    lead OTHER_GOV

Principal Investigators

  • Lourduraj J De Britto, M.D · Vector Control Research Centre, Indian Council of Medical Research, Pondicherry

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2009-02-28
Primary Completion
2011-09-30
Completion
2013-08-31

Countries

  • India

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02005653 on ClinicalTrials.gov