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Measurement of Retinal Auto Fluorescence With a Fluorescence Lifetime Imaging Ophthalmoscope

NCT01981148 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 600

Last updated 2022-12-05

No results posted yet for this study

Summary

Fluorescent lifetime microscopy has emerged as a useful tool to study fluorescent lifetimes in vitro. Fluorescence lifetime represents the average amount of time a fluorophore remains in the excited state following excitation and depends on the fluorophores molecular environment. Fluorescence lifetime ophthalmoscopy (FLIO) is a technique which can quantify fluorescence lifetimes in the human retina in vivo. The purpose of this study is to investigate fluorescence lifetime characteristics in the human retina by using a FLIO. The investigators hypothesize that FLIO will allow to identify areas of retinal metabolic stress such as ischemia by detecting changes in fluorescence lifetimes.

Conditions

  • Autofluorescence Imaging
  • Neuroimaging

Interventions

DEVICE

Fluorescence lifetime ophthalmoscope

All patients and healthy subjects will be imaged with the fluorescence lifetime ophthalmoscope

Sponsors & Collaborators

  • Insel Gruppe AG, University Hospital Bern

    lead OTHER

Principal Investigators

  • Martin Zinkernagel, Prof.Dr.Dr. · Inselspital, University Clinic Ophthalmology

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-02-28
Primary Completion
2025-05-31
Completion
2025-05-31

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01981148 on ClinicalTrials.gov