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Nitrate Patch Use as Treatment of Knee AVN

NCT01979666 · Status: TERMINATED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2024-04-02

No results posted yet for this study

Summary

The pathogenesis of AVN includes a defective blood supply to the knee joint. Local nitrates induce peripheral vasodilation and may improve blood supply to the affected tissue.

This study aims to test whether the use of a nicotine patch may accelerate the healing process from AVN of the knee.

Conditions

  • Necrosis, Avascular, of Bone

Interventions

DRUG

nitrate patch

patients in the study group will get a nitrate patch

DRUG

placebo patch

control group patients will get a placebo patch

DEVICE

MRI scan

MRI scan after 6 weeks of treatment

Sponsors & Collaborators

  • Sheba Medical Center

    lead OTHER_GOV

Principal Investigators

  • avi livneh · Sheba Medical Center

  • arik asman, MD · Sheba Medical Center

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-01-31
Primary Completion
2019-01-31
Completion
2019-01-31

Countries

  • Israel

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01979666 on ClinicalTrials.gov