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Optimization of Systemic Treatment Strategies in Elderly Patients With Advanced Solid Malignancies

NCT01956747 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2020-11-20

No results posted yet for this study

Summary

The purpose of this study is to assess whether the presence of a Myelodysplastic Syndrome (MDS) , Idiopathic Cytopenia of Undetermined Significance (ICUS) or Idiopathic Dysplasia of Undetermined Significance (IDUS), correlates with treatment intensity and clinical outcome in older patients with advanced malignancies receiving palliative chemotherapy. We will study the relation between sarcopenia, comprehensive geriatric assessment en pharmacokinetics with treatment related toxicity as well. We hypothesize that a standardized flow cytometry test to determine bone marrow capacity, a Comprehensive Geriatric Assessment and/or measurement of human body composition with computerized tomography will provide an accurate tool to optimize treatment strategies in elderly patients with advanced malignancies.

Conditions

  • Colorectum Advanced Malignancies
  • Breast Advanced Malignancies
  • Prostate Advanced Malignancies

Interventions

PROCEDURE

venapunction

PROCEDURE

bone marrow punction

Sponsors & Collaborators

  • Amsterdam UMC, location VUmc

    lead OTHER

Eligibility

Min Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-07-31
Primary Completion
2019-12-01
Completion
2019-12-01

Countries

  • Netherlands

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01956747 on ClinicalTrials.gov