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Relationship Between CETP Deficiency and Atherosclerosis in Patients With Hyperalphalipoproteinemia

NCT01916512 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 1500

Last updated 2015-04-15

No results posted yet for this study

Summary

The aim of this study is to determine whether high high density lipoprotein-cholesterol(HDL-C) level and low Cholesteryl Ester Transfer Protein(CETP) activity is atherogenic or not in subjects who received health checkups. We investigate the association between CETP activities and the severity of atherosclerosis assessed by intima-media thickness (IMT) and compare the atherogenic change between in subjects with high HDL-C level, low HDL-C level, high CETP activities and low CETP activities by examining the morbidity rate of atherogenic diseases, the rate of ischemic electrocardiography(ECG) change, Calc Score of artery from chest X-ray, Ankle Brachial Index/Pulse Wave Velocity and various serum atherogenic markers. And we also examine the correlation between normal lipid profile and concentration, activity and function of surface lipoprotein in subjects with variety of lipoprotein levels, including patients with hyper-LDL-cholesterolemia, hyper-HDL-cholesterolemia with low or no CETP activity, patients with high level of remnant cholesterol or hyperlipoproteinemia of apolipoprotein(Apo)B-48.

Conditions

  • Low CETP Activity
  • CETP Deficiency
  • Hyperalphalipoproteinemia
  • Hyper-LDL-cholesterolemia
  • High Level of Remnant Cholesterol

Sponsors & Collaborators

Principal Investigators

  • Shizuya Yamashita, MD, PhD, FAHA, FJCC · Osaka University Graduate School of Medicine

  • Etsuko Fushimi, MD, PhD · Hiraga General Hospital

  • Hiroshi Itoh, MD, PhD · Akita University Graduate School of Medicine

  • Norimichi Nakajima, MD · Nakajima Naika Clinic

  • Yoshinobu Ikeda, MD · Ikeda Clinic

  • Yuji Matsuzawa, MD, PhD · Sumitomo Hospital

Eligibility

Min Age
40 Years
Max Age
100 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2012-02-29
Primary Completion
2016-03-31

Countries

  • Japan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01916512 on ClinicalTrials.gov