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N-PhenoGENICS: Neurocognitive-Phenome, Genome, Epigenome and Nutriome In Childhood Leukemia Survivors

NCT01913093 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 204

Last updated 2020-10-08

No results posted yet for this study

Summary

To find possible therapeutic targets to help prevent long-term brain and behavioural side effects in survivors of childhood leukemia that may have been caused by chemotherapy (Treatment-Related late Adverse Neuro-Cognitive Effects: TRANCE). The study hypothesis is that genetic variations of the elements in the folate-related cycles and methotrexate disposition networks are associated with the deficit phenotype (TRANCE) of childhood leukemia survivors.

Conditions

  • Childhood Leukemia Survivors

Sponsors & Collaborators

  • Canadian Institutes of Health Research (CIHR)

    collaborator OTHER_GOV

  • Canadian Cancer Society (CCS)

    collaborator OTHER

  • C17 Council

    collaborator OTHER

  • Garron Family Cancer Centre

    collaborator OTHER

  • Pediatric Oncology Group of Ontario

    collaborator OTHER

  • The Hospital for Sick Children

    lead OTHER

Principal Investigators

  • Dr. Shinya Ito, MD · The Hospital for Sick Children

  • Dr. Sharon Guger · The Hospital for Sick Children

  • Dr. Johann Hitzler · The Hospital for Sick Children

  • Dr. Deborah L O'Connor · The Hospital for Sick Children

  • Dr. Russell Schachar · The Hospital for Sick Children

  • Dr. Brenda Spiegler · The Hospital for Sick Children

  • Dr. Rosanna Weksberg · The Hospital for Sick Children

Eligibility

Min Age
8 Years
Max Age
20 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-07-31
Primary Completion
2018-01-31
Completion
2019-06-30

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01913093 on ClinicalTrials.gov