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Anesthetic Technique on Immune Response in Colorectal Cancer

NCT01902849 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 70

Last updated 2014-03-11

No results posted yet for this study

Summary

Knowing the fact that the anesthetic substances can alter the immune response during the surgery, the purpose of the study is to evaluate the influence of two general anesthetic techniques - inhalation vs. total intravenous anesthesia on the immune response in patient with colorectal surgery for neoplastic disease, evaluated by the plasma level of the interleukins 6 and 10(IL6, IL10).

Conditions

  • Colorectal Neoplasms

Interventions

OTHER

blood sampling for IL measurement

Blood sampling to determine interleukins IL6 , IL10 plasma levels are drawn at the following moments: * T0- before the induction of anesthesia (venous cannula insertion time) * T1- after induction but before starting surgery * In the group I (TIVA -TCI) when the plasma concentration of propofol is 3-3.5 ng/ml * In group II (ISOFLURANE) when concentration of isoflurane in exhaled air (Et Isoflurane) is between 0.3-0.5% * T2, T3- at 2 and 24 hours after surgery

Sponsors & Collaborators

  • Iuliu Hatieganu University of Medicine and Pharmacy

    lead OTHER

Principal Investigators

  • Simona C Margarit, lecturer · University of Medicine and Pharmacy Iuliu Hatieganu

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2012-02-29
Primary Completion
2013-07-31
Completion
2013-08-31

Countries

  • Romania

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01902849 on ClinicalTrials.gov