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Innate Immune Response to (An)Aerobic Exercise in Rowing Athletes

NCT01893762 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 16

Last updated 2014-07-01

No results posted yet for this study

Summary

Exercise induces innate immune response activation in athletes. The response starts during exercise and lasts for approximately 24 hours. This innate immune response shows similarities to the innate immune activation observed in, for example, bacterial infection and trauma. Immediately after exercise, athletes develop leukocytosis and cytokine production is altered towards an inflammatory pattern. However, to gain insight in immune response, a detailed cell receptor expression is required. To investigate the physiological innate immune response to exercise, we developed a model in rowers.

Aim: To determine the type and degree of cellular inflammatory response in peripheral blood of elite rowing athletes after both anaerobe and aerobe exercise.

Study design:

Investigator driven, monocenter observational pilot study.

Study population: 16 healthy, non-asthmatic, human volunteers, 18-25 year old. All competitive rowing athletes.

Conditions

  • Upper Respiratory Tract Infections
  • URTI

Interventions

BIOLOGICAL

Aerobic exercise

Aerobic exercise: 2x30 min on an indoor rowing machine at 75% of Maximum heart rate

BIOLOGICAL

Anaerobic exercise

Anaerobic exercise: 3x1000m maximum effort, on an indoor rowing machine

Sponsors & Collaborators

  • UMC Utrecht

    lead OTHER

Principal Investigators

  • Bart Hilvering, M.D. · UMC Utrecht, department of Respiratory Medicine

  • Leo Koenderman, Professor · UMC Utrecht, department of Respiratory Medicine

  • Daan Switters · UMC Utrecht

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
25 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-05-31
Primary Completion
2013-12-31
Completion
2013-12-31

Countries

  • Netherlands

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01893762 on ClinicalTrials.gov