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Accelerated Diffusion MRI for Diagnosis of Hungtington Disease

NCT01884181 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 80

Last updated 2018-07-18

No results posted yet for this study

Summary

The hypotheses of the project are

1. Diffusion MRI using compressed sensing could have reduced motion sensitivity and improved susceptibility related artifact because of accelerated acquisition.
2. The macromolecule deposition in the brain of patients with Huntington Disease (HD) can lead to changes detectible by diffusion MRI.

To validate the hypothesis that the new accelerated diffusion MRI technique could produce a new biomarker for HD, patients with Huntington Disease will be recruited. The diffusion index will be calculated using accelerated acquisition. The diagnostic performance will be evaluated for data reconstructed with and without acceleration. The correlation with the disease severity will be assessed.

Conditions

  • Huntington Disease

Sponsors & Collaborators

  • National Health Research Institutes, Taiwan

    collaborator OTHER

  • Wang . Jiun-Jie

    lead OTHER

Principal Investigators

  • Jiun-Jie Wang, PhD · ChangGung University

Eligibility

Min Age
20 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2014-01-31
Primary Completion
2017-12-31
Completion
2017-12-31

Countries

  • Taiwan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01884181 on ClinicalTrials.gov