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Investigation Into the Role of GTN & RIPC in Cardiac Surgery

NCT01864252 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 192

Last updated 2019-09-25

No results posted yet for this study

Summary

The purpose of this study is to determine whether Glyceryl Trinitrate (GTN) reduces injury to the heart during heart-lung bypass surgery in combination with the newer technique of remote ischaemic preconditioning (RIPC).

Conditions

  • Myocardial Reperfusion Injury

Interventions

OTHER

Remote ischaemic preconditioning

3 cycles of 5 minutes to arm and legs

DRUG

IV Normal saline

Normal saline IV started prior to knife to skin at a rate of 2-5 mls/h and stopped just after weaning off bypass.

DRUG

IV Glyceryl trinitrate 2-5ml/h

IV GTN given during surgery started prior to knife to skin and stopped after weaning off cardiopulmonary bypass.

Sponsors & Collaborators

  • University College London Hospitals

    collaborator OTHER

  • University College, London

    lead OTHER

Principal Investigators

  • Derek Yellon, PhD DSc FRCP · The Hatter Cardiovascular Institute

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-01-31
Primary Completion
2018-10-31
Completion
2019-02-28

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01864252 on ClinicalTrials.gov