Mitoxantrone and Clofarabine for Treatment of Recurrent NHL or Acute Leukemia
NCT01842672 · Status: COMPLETED · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 41
Last updated 2022-10-25
Summary
The combination of mitoxantrone and clofarabine as reinduction therapy will be safe, well tolerated and effective in children, adolescents and young adults with poor risk refractory/relapsed acute leukemia and high grade non-Hodgkin lymphoma (NHL).
Conditions
- Acute Lymphoblastic Leukemia
- Acute Myelogenous Leukemia
- Lymphoblastic Lymphoma
- Diffuse Large B-cell Lymphoma
- Burkitt Lymphoma/Leukemia
Interventions
- DRUG
-
Clofarabine
Dose Escalation of Clofarabine
- DRUG
-
Mitoxantrone
Sponsors & Collaborators
-
New York Medical College
lead OTHER
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Max Age
- 30 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2013-03-31
- Primary Completion
- 2021-08-31
- Completion
- 2022-09-30
Countries
- United States
Study Locations
More Related Trials
-
Mitoxantrone, Etoposide, and Cytarabine (MEC) Plus Lenalidomide for Relapsed or Refractory Acute Myeloid Leukemia
NCT03118466 ·Status: COMPLETED ·Phase: PHASE2
-
Sorafenib in Combination With Cytarabine and Clofarabine in Patients With Refractory or Relapsed Hematologic Malignancies
NCT00908167 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of Clofarabine in Combination With Etoposide and Cyclophosphamide in Children With Acute Leukemias.
NCT00315705 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Clofarabine-cyclophosphamide as Salvage Therapy for Refractory and Relapsed Acute Lymphoblastic Leukemia (ALL) Adults
NCT01462253 ·Status: COMPLETED ·Phase: PHASE2
-
A Phase II Open-Label Study of High-Dose Cytarabine and Clofarabine in Adult Patients With Refractory or Relapsed Acute Myelogenous Leukemia or Refractory or Relapsed Acute Lymphoblastic Leukemia
NCT01656031 ·Status: COMPLETED ·Phase: PHASE2
-
CPI-613, Cytarabine, and Mitoxantrone Hydrochloride in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia
NCT01768897 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase I Study Investigating the Combination of Cladribine, Low Dose Cytarabine and Sorafenib Alternating With Decitabine in Pediatric Relapsed and Refractory Acute Leukemias
NCT06474663 ·Status: WITHDRAWN ·Phase: PHASE1
-
Clofarabine Bone Marrow Cytoreduction
NCT00724009 ·Status: COMPLETED ·Phase: PHASE2
-
Lintuzumab-Ac225 in Combination with Cladribine + Cytarabine + Filgastrim + Mitoxantrone (CLAG-M) for Relapsed/Refractory Acute Myeloid Leukemia
NCT03441048 ·Status: COMPLETED ·Phase: PHASE1
-
Use of Topotecan in Patients With Refractory Acute Leukemia
NCT00100477 ·Status: COMPLETED ·Phase: PHASE2
-
Clofarabine and Low Dose Total Body Irradiation as a Preparative Regimen for Stem Cell Transplant in Leukemia.
NCT01041508 ·Status: COMPLETED ·Phase: PHASE1
-
Phase I Dose-Escalation Trial of Clofarabine Followed by Escalating Doses of Fractionated Cyclophosphamide in Children With Relapsed or Refractory Acute Leukemias
NCT00852709 ·Status: TERMINATED ·Phase: PHASE1
-
Phase II Study of Clofarabine in Adult Patients With Refractory or Relapsed Acute Myelogenous Leukemia
NCT00044889 ·Status: COMPLETED ·Phase: PHASE2
-
T2007-002 Clofarabine, Etoposide, Cyclophosphamide in Relapsed Acute Myelogenous Leukemia (AML)
NCT00939653 ·Status: TERMINATED ·Phase: PHASE2
-
Clofarabine and Cyclophosphamide Combination in Acute Lymphoblastic Leukemia Patients
NCT00412243 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Clofarabine and Daunorubicin in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia
NCT00814164 ·Status: TERMINATED ·Phase: PHASE2
-
Lenalidomide and Combination Chemotherapy in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia
NCT01904643 ·Status: TERMINATED ·Phase: PHASE1
-
Cytarabine and Clofarabine in Treating Patients With Refractory or Relapsed Acute Myeloid Leukemia or Acute Lymphoblastic Leukemia
NCT00295841 ·Status: COMPLETED ·Phase: PHASE1
-
Clofarabine and Cyclophosphamide in Treating Patients With Relapsed or Refractory Acute Leukemia, Chronic Myelogenous Leukemia, or Myeloproliferative Disorders
NCT00293410 ·Status: COMPLETED ·Phase: PHASE1
-
Clofarabine and Cytarabine in Treating Patients With Acute Myeloid Leukemia With Minimal Residual Disease
NCT00863434 ·Status: TERMINATED ·Phase: PHASE2
-
Dose Escalation of Clofarabine in Combination With Cytarabine and Idarubicin as Induction Therapy in High Risk AML
NCT01534702 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Oral Clofarabine for Acute Myeloid Leukemia
NCT00727766 ·Status: COMPLETED ·Phase: PHASE1
-
Bendamustine and Mitoxantrone in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia
NCT00274963 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of Imatinib With Reinduction Chemotherapy Using Mitoxantrone, Etoposide and Cytarabine in Patients With Relapsed/Refractory C-kit Positive (AML) Acute Myeloid Leukemia
NCT01126814 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Mitoxantrone Hydrochloride Liposome Combined With Chemotherapy in Untreated de Novo Acute Myeloid Leukemia
NCT05941585 ·Status: COMPLETED ·Phase: NA