Breast Cancer Proteomics and Molecular Heterogeneity
NCT01840293 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 1780
Last updated 2025-12-19
Summary
Primary objective:
The primary objective is to define the proteomic and molecular characteristics of primary and recurrent/ metastatic breast tumours with special focus on the expression of S100 protein and the estrogen receptor (ER), progesterone receptor (PR) and epidermal growth factor receptor 2 (HER2) genes
Secondary objective:
* To expand our understanding of the complex molecular pathways dictating the progression of breast cancer and their response to different treatment regimes.
* To relate proteomic findings to survival data
* To identify potential serum markers of breast cancer progression
Conditions
- Primary Breast Cancer
- Recurrent/Metastatic Breast Cancer
Sponsors & Collaborators
-
Cancer Trials Ireland
lead NETWORK
Eligibility
- Min Age
- 18 Years
- Sex
- FEMALE
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2013-02-28
- Primary Completion
- 2029-12-31
- Completion
- 2038-01-31
Countries
- Ireland
Study Locations
More Related Trials
-
Genes That Affect Disease Progression in Women With Newly Diagnosed or Metastatic Breast Cancer
NCT00463034 ·Status: UNKNOWN
-
Breast Cancer Molecular Analysis Protocol
NCT01855503 ·Status: COMPLETED
-
Molecular and Cellular Analysis of Breast Cancer
NCT02243397 ·Status: COMPLETED
-
Study of Circulating and Tumor Biomarkers in Breast Cancer Patients
NCT01866202 ·Status: UNKNOWN
-
Breast Cancer Tumor Heterogeneity
NCT02108561 ·Status: UNKNOWN
-
Gene Polymorphisms and Gene Products as Biological Markers of Aging and Correlation With Clinical Geriatric Assessment, Tolerance of Chemotherapy and Outcome in Elderly Breast Cancer Patients
NCT00849758 ·Status: COMPLETED
-
Molecular Profiling of Stage II and III Breast Cancer in Latin American Women Receiving Standard-of-Care Treatment
NCT02326857 ·Status: COMPLETED
-
Breast Cancer 2-PREVENT Translational Center of Excellence (TCE) - Metastatic Markers of Recurrent Tumor Phenotype for Breast Cancer
NCT02530008 ·Status: ACTIVE_NOT_RECRUITING
-
Analysis of Brain Metastasis in Patients With Breast Cancer, With and Without Over-Expression of HER-2
NCT00071383 ·Status: COMPLETED
-
Homologous Recombination Repair Pathway Gene Mutation Spectrum in Chinese Breast Cancer Patients
NCT05901025 ·Status: NOT_YET_RECRUITING
-
Peptide Profiles of Women Undergoing Breast Biopsy
NCT00587821 ·Status: COMPLETED
-
Gene Expression Profiling of Metastatic Breast Cancer Predict the Therapeutic Response to Chemotherapy
NCT01198301 ·Status: COMPLETED
-
Prognosis and Targeted Therapy Related Molecular Screening Program for Patients of Breast Cancer in China
NCT03792529 ·Status: UNKNOWN
-
Circulating miRNAs.
NCT01722851 ·Status: COMPLETED
-
Transformation Potential of E2 Exposed Breast Cancer Susceptibility Gene Mutation Heterozygous Epithelial Breast Cells
NCT01907438 ·Status: UNKNOWN
-
Prevalence of Emerging Treatment-induced Mutations in Metastatic ER-positive Breast Cancer.
NCT06417801 ·Status: RECRUITING
-
Study of Biomarkers in Tissue Samples From Patients With Breast Cancer
NCT01004796 ·Status: UNKNOWN
-
Evaluation of Prognostic Monitoring for Women Who Have Completed Standard Treatment for Breast Cancer
NCT04145960 ·Status: UNKNOWN
-
Clinical, Histological and In-depth Molecular Characterization as Well as Experimental Models of Liver Metastasis From Patients With Breast Cancer in Order to Identify New Potential Treatment Avenues.
NCT05720676 ·Status: UNKNOWN
-
Molecular Signature for Breast Cancer
NCT05724407 ·Status: UNKNOWN
-
HER2-positive Breast Cancer Registry
NCT06603597 ·Status: RECRUITING
-
Investigation of Gene Mutations in Patients With Triple-negative and Patients With HER2+ Breast Cancer Adenocarcinoma
NCT04365790 ·Status: UNKNOWN
-
A Study on the Epidemiology and Testing of Human Epidermal Growth Factor-Receptor 2 (HER2) in Breast Cancer in Germany
NCT02666261 ·Status: COMPLETED
-
Identification of Genes That Predict Local Recurrence in Samples From Patients With Breast Cancer Treated on NSABP-B-28
NCT01420185 ·Status: UNKNOWN
-
Using Bio Markers to Predict Disease Recurrence and Cognitive Function in High Risk Breast Ca
NCT00756132 ·Status: COMPLETED