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Sex-specific Association With Kidney Disease

NCT01810822 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 1396

Last updated 2013-03-14

No results posted yet for this study

Summary

Oxidative stress is involved in the pathophysiology of diabetic nephropathy. The superoxide-generating nicotinamide adenine dinucleotide phosphate-oxidase 2 (NOX2, encoded by the CYBB gene) and the antioxidant enzyme glutathione peroxidase 4 (GPX4) play opposing roles in the balance of cellular redox status. In the present study, we investigated associations of single nucleotide polymorphisms (SNPs) in the regulatory regions of CYBB and GPX4 with kidney disease in patients with type 1 diabetes.

Conditions

  • Diabetic Nephropathy

Sponsors & Collaborators

  • University of Sao Paulo General Hospital

    lead OTHER

Principal Investigators

  • Maria L Côrrea-Giannela, Doctor · Clinical Hospital/Faculty of Medicine from University of São Paulo

  • Gilberto Velho, Doctor · INSERM U695

Eligibility

Min Age
11 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
1994-05-31
Primary Completion
1994-05-31
Completion
2012-10-31

Countries

  • Brazil

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01810822 on ClinicalTrials.gov