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Study of [11C]DPA-713 for Temporal Lobe Epilepsy

NCT01793532 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 38

Last updated 2019-12-16

No results posted yet for this study

Summary

Background:

\- Some people with epilepsy have an epileptic focus, a small part of the brain that is the starting point of the seizure. This focus is like an irritant or an inflammation, and helps cause the seizure. People with epilepsy that affects the temporal lobe of the brain often have an epileptic focus. Researchers want to look at the epileptic focus by using a drug that attaches to a protein associated with inflammation. An imaging study with the drug will show how much inflammation is in the area of the brain where the seizures start. The drug, called \[11C\]DPA-713, will be tested for its effectiveness in people with temporal lobe epilepsy. Its effects will be compared with imaging studies given to healthy volunteers.

Objectives:

\- To see if \[11C\]DPA-713 can show the inflammation in the epileptic focus of seizures.

Eligibility:

* Individuals at least 18 years of age who have temporal lobe epilepsy.
* Healthy volunteers at least 18 years of age.

Design:

* Participants will have three outpatient visits to the National Institutes of Health Clinical Center. The visits will last from 2 to 5 hours.
* Participants will be screened with a physical exam, neurological exam, and medical history. Blood samples will be collected before the start of the study.
* Participants will have a positron emission tomography (PET) scan. This scan will be used to look at brain chemistry and function. The study drug will be given during the scan to see how well it shows points of inflammation in the brain. Some participants will provide additional blood samples during the PET scan.
* Participants will also have a magnetic resonance imaging (MRI) scan. This scan will look at the structure of the brain.

Conditions

Sponsors & Collaborators

  • National Institute of Mental Health (NIMH)

    lead NIH

Principal Investigators

  • Robert B Innis, M.D. · National Institute of Mental Health (NIMH)

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-01-31
Primary Completion
2016-06-08
Completion
2016-06-08

Countries

  • United States

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01793532 on ClinicalTrials.gov