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Preventing Epilepsy After Traumatic Brain Injury With Topiramate

NCT00598923 · Status: TERMINATED · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 6

Last updated 2017-06-27

No results posted yet for this study

Summary

Our hypothesis is that topiramate will reduce acute seizures after traumatic brain injury and will help prevent the development of epilepsy after traumatic brain injury.

Conditions

Interventions

DRUG

topiramate

100 mg twice per day for 3 months

DRUG

topiramate

100 twice per day for 6 days after loading dose of phenytoin

DRUG

phenytoin

loading dose of 20 mg/kg and then 300 mg/day for total of 7 days

Sponsors & Collaborators

Principal Investigators

  • Marc A Dichter, MD, PhD · University of Pennsylvania

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2004-11-30
Primary Completion
2009-02-28
Completion
2009-02-28

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00598923 on ClinicalTrials.gov