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Non-Invasive Treatment of Abdominal Aortic Aneurysm Clinical Trial

NCT01756833 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 261

Last updated 2021-11-26

Study results available
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Summary

The primary aim of this study is to determine if doxycycline (100 mg bid) will inhibit (by at least 40%) the increase in greatest transverse diameter of small abdominal aortic aneurysms (3.5-5.0 cm in men, 3.5-4.5 cm in women) over a 24-month period of observation in comparison to a placebo-treated control group.

Conditions

  • Aneurysm

Interventions

DRUG

Doxycycline

100 mg po bid

DRUG

Placebo

capsule identical to the doxycycline capsule

Sponsors & Collaborators

  • National Institute on Aging (NIA)

    collaborator NIH

  • University of Maryland, Baltimore

    lead OTHER

Principal Investigators

  • Michael L Terrin, MD · University of Maryland, Baltimore

  • Bernard T Baxter, MD · University of Nebraska

  • Jonathan Matsumura, MD · University of Wisconsin Medical Center

  • John Curci, MD · Vanderbilt University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
55 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-05-31
Primary Completion
2019-07-23
Completion
2019-07-23

Countries

  • United States

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01756833 on ClinicalTrials.gov