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Doxycycline Boosted Therapy in Lyme Borreliosis: DoBo Study.

NCT07230028 · Status: NOT_YET_RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 50

Last updated 2025-11-17

No results posted yet for this study

Summary

The goal of this clinical trial is to learn if hydroxychloroquine works to treat long-term complaints attributed to Lyme borreliosis in adults. The main questions it aims to answer are:

Does addition of hydroxychloroquine reduce physical complaints? Researchers will compare hydroxychloroquine to a placebo (a look-alike substance that contains no drug) to see if hydroxychloroquine works to treat Lyme borreliosis.

Participants will:

Take hydroxychloroquine or a placebo two times a day during 28 days. Visit the clinic 4 times in one year for checkups and tests.

Conditions

  • Lyme Borreliosis, Nervous System

Interventions

DRUG

Hydroxychloroquin

Added to the standard of care for Lyme Disease

DRUG

Placebo

Standard of care in combination with placebo

DRUG

Doxycycline

Standard of care

Sponsors & Collaborators

  • Ministerie van Volksgezondheid, Welzijn en Sport

    collaborator UNKNOWN

  • Radboud University Medical Center

    lead OTHER

Principal Investigators

  • Hadewych Ter Hofstede, Dr. · Radboud University Medical Center

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-03-01
Primary Completion
2026-11-01
Completion
2027-11-01

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Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07230028 on ClinicalTrials.gov