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Duration of Antibiotics for the Treatment of Gram-negative Bacilli Bacteremia

NCT01737320 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 604

Last updated 2019-04-09

No results posted yet for this study

Summary

The investigators plan an open label randomized controlled trial to compare short-course antibiotic therapy (\<=7 days) versus longer treatment (\>7 days). The investigators will include hospitalized patients with gram-negative bacteremia. The investigators primary objective is to investigate the safety and efficacy of short-course antibiotics.

Conditions

  • Gram Negative Bacteremia

Interventions

DRUG

short-course antibiotic treatment

On day 7 of appropriate intravenous or oral antibiotic treatment for the bacteremic episode (day 1 is the first day of appropriate antibiotic therapy), patients will be randomized to: 1. Intervention group - antibiotic treatment stopped on day 7 2. Control group - antibiotic treatment continued for 14 days according to accepted hospital local guidelines.

DRUG

accepted prolonged antibiotic treatment

Sponsors & Collaborators

  • Rabin Medical Center

    lead OTHER

Principal Investigators

  • Dafna Yahav, MD · Rabin Medical Center

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-01-31
Primary Completion
2018-03-31
Completion
2018-03-04

Countries

  • Israel
  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01737320 on ClinicalTrials.gov