Daptomycin as Adjunctive Therapy for Staphylococcus Aureus Bacteremia
NCT02972983 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 102
Last updated 2020-09-22
Summary
The purpose of our study is to examine the effects of a second antibiotic, daptomycin, in combination with a beta lactam antibiotic on treating bloodstream infection caused by methicillin-susceptible S. aureus.
Conditions
- Methicillin Susceptible Staphylococcus Aureus Septicemia
- Bacteremia
Interventions
- DRUG
-
Daptomycin
Adjuvant therapy for up to five days
- OTHER
-
Placebo
Placebo
Sponsors & Collaborators
-
McGill University Health Centre/Research Institute of the McGill University Health Centre
lead OTHER
Principal Investigators
-
Todd C Lee, MD · McGill University Health Centre/Research Institute of the McGill University Health Centre
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- QUADRUPLE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2016-12-01
- Primary Completion
- 2019-07-31
- Completion
- 2019-09-30
Countries
- Canada
Study Locations
More Related Trials
-
Vancomycin Versus Daptomycin for the Treatment of Methicillin Resistant Staphylococcus Aureus (MRSA) Bacteremia
NCT01975662 ·Status: TERMINATED ·Phase: PHASE2
-
Safety & Efficacy of Daptomycin Versus Standard of Care (SOC) in 1 - 17 Year Olds With Staphylococcus Aureus Bacteremia (MK-3009-005)
NCT01728376 ·Status: COMPLETED ·Phase: PHASE4
-
Daptomycin for the Treatment of Infections Due to Gram-Positive Bacteria
NCT00055198 ·Status: TERMINATED ·Phase: PHASE3
-
Combination Cefazolin With Ertapenem for Methicillin-susceptible Staphylococcus Aureus Bacteremia
NCT04886284 ·Status: RECRUITING ·Phase: PHASE2
-
Subcutaneous Daptomycin in Healthy Volunteers (DAPTOSC)
NCT04434300 ·Status: COMPLETED ·Phase: PHASE1
-
Dalbavancin Versus Standard Antibiotic Therapy for Catheter-related Bloodstream Infections Due to Staphylococcus Aureus
NCT05117398 ·Status: RECRUITING ·Phase: PHASE3
-
Daptomycin for the Treatment of Severe Necrotizing Soft-Tissue Infections
NCT00261807 ·Status: COMPLETED ·Phase: NA
-
Study of Single Dose Daptomycin in Pediatric Patients With Gram-positive Infection for Which They Are Receiving Standard Antibiotics
NCT00136292 ·Status: COMPLETED ·Phase: PHASE1
-
Cotrimoxazole Versus Vancomycin for Invasive Methicillin-resistant Staphylococcus Aureus Infections
NCT00427076 ·Status: COMPLETED ·Phase: PHASE3
-
PK and Safety Evaluation of Daptomycin in Children Ages 2-6 With Proven or Suspected Gram-positive Infections
NCT00679835 ·Status: COMPLETED ·Phase: PHASE1
-
Pharmacokinetic Variability of Daptomycin During Prolonged Therapy for Bone and Joint Infections
NCT03209921 ·Status: COMPLETED
-
Vancomycin vs. Vancomycin Plus Gentamycin in Treatment of MRSA Infection
NCT00304811 ·Status: COMPLETED ·Phase: PHASE4
-
DOTS: Dalbavancin as an Option for Treatment of Staphylococcus Aureus Bacteremia
NCT04775953 ·Status: COMPLETED ·Phase: PHASE2
-
Phase 2 Safety and Efficacy Study of Daptomycin in Complicated Skin and Skin Structure Infections
NCT00426933 ·Status: COMPLETED ·Phase: PHASE2
-
Direct Thrombin Inhibitors Versus LMWH in Staphylococcus Aureus Bacteraemia
NCT01911624 ·Status: COMPLETED ·Phase: PHASE2
-
Dabigatran vs. Oral Anti-Xa Inhibitors in S. Aureus Bacteremia
NCT06650501 ·Status: RECRUITING ·Phase: PHASE4
-
Catheter Related - Gram Positive Bloodstream Infections
NCT00467272 ·Status: COMPLETED ·Phase: PHASE2
-
Application of Daptomycin in MRSA Infected Diabetic Foot in Comparison to Vancomycin Treatment
NCT01199783 ·Status: TERMINATED ·Phase: PHASE3
-
Trial for the Treatment of Extensively Drug-Resistant Gram-negative Bacilli (OVERCOME)
NCT01597973 ·Status: COMPLETED ·Phase: PHASE3
-
Safety, Efficacy and Pharmacokinetics of CF-301 vs. Placebo in Addition to Antibacterial Therapy for Treatment of S. Aureus Bacteremia
NCT03163446 ·Status: COMPLETED ·Phase: PHASE2
-
Treatment Algorithm to Reduce the Use of Vancomycin in Adults With Blood Stream Infection
NCT01191840 ·Status: COMPLETED ·Phase: PHASE2
-
Subphenotype- and Complication-guided Adjunctive Fosfomycin Therapy for Staphylococcus Aureus Bacteraemia
NCT07155590 ·Status: ACTIVE_NOT_RECRUITING
-
Ceftobiprole in the Treatment of Hospitalized Patients With Staphylococcus Aureus Bacteremia
NCT00505258 ·Status: WITHDRAWN ·Phase: PHASE2
-
Staphylococcus Aureus Bacteremia Antibiotic Treatment Options
NCT01792804 ·Status: COMPLETED ·Phase: PHASE3
-
Short Versus Long Duration of Therapy for Streptococcus Pneumoniae Bloodstream Infections
NCT06096025 ·Status: ACTIVE_NOT_RECRUITING