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Factors Affecting Methamphetamine and Opiates Drug Testing

NCT01736332 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 29

Last updated 2019-12-17

No results posted yet for this study

Summary

Background:

\- Some legal over-the-counter drugs (such as Vicks VapoInhaler ) and some foods (such as poppy seeds) may cause a positive screening drug test. This might look like someone used illegal drugs (such as methamphetamines or opiates) when they did not. Researchers are studying how the body handles chemicals that may test like illegal drugs and for how long they may be detected in the body. Blood, saliva, and urine samples will be collected. This study may help improve the effectiveness and accuracy of drug tests.

Objectives:

\- To see how the body handles chemicals that may produce positive screening tests and how additional testing can eliminate positive drug tests from over-the-counter drugs and food.

Eligibility:

\- Healthy volunteers between 18 and 65 years of age.

Design:

* Participants are screened with a physical exam, medical history, laboratory tests, and ECG.
* This study involves an overnight stay on a secure research unit and 2 days of tests.
* On the first day, participants will take Vicks VapoInhaler (two inhalations in each nostril) every 2 hours from 9 a.m. to 7 p.m. They will also take a drink containing poppy seeds twice (at about 9 a.m. and 5 p.m.).
* On the morning of the second day, participants will take the Vicks VapoInhaler just once. They will be discharged around 5 p.m.
* On both days, participants will provide blood and saliva samples several times throughout the day. All of their urine will be collected during the 2 study days....

Conditions

  • Opiates
  • Healthy

Interventions

DRUG

Vicks VapoInhaler

2 inhalations each nostril every 2 hours for 6 doses on day 1, one dose on morning of day 2

OTHER

Poppy seeds

45 g in liquid at 9 am and 5 pm on day 1

Sponsors & Collaborators

  • National Institute on Drug Abuse (NIDA)

    lead NIH

Principal Investigators

  • Marilyn Huestis, Ph.D. · National Institute on Drug Abuse (NIDA)

Study Design

Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2012-07-19
Primary Completion
2014-01-31
Completion
2014-01-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01736332 on ClinicalTrials.gov