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Improvement Assessment of Coronary Flow Dysfunction Using Fundamental Fluid Dynamics

NCT01719016 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 68

Last updated 2026-05-07

No results posted yet for this study

Summary

Diagnosis of relative contributions of large artery blockages and microvascular blockages is very much needed in the treatment of coronary artery disease. In order to achieve this, two novel parameters, pressure drop coefficient (CDP), which combines flow and pressure readings and Lesion flow coefficient (LFC), which combines anatomical details of the lesion with pressure and flow readings, are being investigated.

Conditions

Interventions

PROCEDURE

Cardiac PET, Coronary catheterization

Patients would under go a Cardiac rest and stress PET scan and include the following drug administration: 1. N-13 Ammonia radionuclide - Two doses, 10 mCi for rest, 20 mCi for stress 2. Lexiscan - stress agent for PET scan Patients would also undergo Coronary catheterization including the following drug administration and device usage: 1. Combowire to obtain pressure and flow readings on Combomap machine (Volcano Therapeutics, CA). 2. Adenosine - stress agent during catheterization, 140 ug/Kg/min

Sponsors & Collaborators

  • University of Cincinnati

    lead OTHER

Principal Investigators

  • Rupak K Banerjee, PhD · University of Cincinnati , CVAMC

  • Mohamed Effat, MD · Univesity of Cincinnati, University Hospital

  • Imran Arif, MD · University of Cincinnati and University Hospital

  • Hanan Kerr, MD · University of Cincinnati

Eligibility

Min Age
18 Years
Max Age
100 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2010-08-31
Primary Completion
2026-07-30
Completion
2026-07-30

Countries

  • United States

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01719016 on ClinicalTrials.gov