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Rapid Acclimatization to Hypoxia at Altitude

NCT01702025 · Status: COMPLETED · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 41

Last updated 2014-10-24

Study results available
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Summary

In low oxygen environments, such as altitude, some adults may become ill and suffer from acute mountain sickness. Further, all adults will find that exercising becomes much more difficult when compared with exercise at lower altitudes (e.g. sea-level). The purpose of this investigation is to study the effects of two drugs that may help people adjust to high-altitude quickly, prevent them from becoming ill and improve their exercise performance. The drugs are Methazolamide and Aminophylline.

Conditions

  • Physiological Function in Low Oxygen Environment

Interventions

DRUG

Placebo

Yellow corn meal in gel capsules

DRUG

Aminophylline

National Drug Code (NDC) 0143-1020-01

DRUG

Methazolamide

NDC 0781-1072-01

DRUG

Aminophylline+Methazolamide

NDC 0143-1020-01 and NDC 0781-1072-01

Sponsors & Collaborators

  • Defense Advanced Research Projects Agency

    collaborator FED

  • University of Colorado, Denver

    collaborator OTHER

  • Colorado State University

    lead OTHER

Principal Investigators

  • Christopher Bell, PhD · Colorado State University

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2012-06-30
Primary Completion
2012-12-31
Completion
2012-12-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01702025 on ClinicalTrials.gov