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Oral Health Assessment in Rheumatoid Arthritis and Other Autoimmune Diseases-- Anti- TNF Substudy

NCT01698515 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 20

Last updated 2016-08-31

No results posted yet for this study

Summary

The objective of this study is to evaluate the effect of Tumor Necrosis Factor (TNF) inhibition on oral parameters in patients with RA and to examine changes in levels of proinflammatory cytokines in serum, gingival crevicular fluid (GCF), and saliva at an early time point (6-8 wk) and a later time point (14-16 wk) after the initiation of therapy in relation to concomitant assessment of Rheumatoid arthritis (RA) and oral clinical variables.

The purposes of the study are to:

1. Determine if oral periodontal parameters are affected by TNF inhibition;
2. Examine relationships between periodontal variables and RA variables with TNF inhibition;
3. Determine if there may be potential early response markers of clinical RA response seen using ultrasensitive analysis of oral or serum cytokines.

Conditions

Sponsors & Collaborators

Principal Investigators

  • Clifton O Bingham, MD · Johns Hopkins University

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2012-08-31
Primary Completion
2016-06-30
Completion
2016-06-30

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01698515 on ClinicalTrials.gov