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Diameter Changes of Retinal Vessels During Hypoxia

NCT01689090 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 58

Last updated 2018-10-16

No results posted yet for this study

Summary

The primary objective is to study if an inhibition of nitric oxide and/or prostaglandins affect the diameter changes of retinal vessels observed during hypoxia. Diameter changes are studied using the Dynamic Vessel Analyzer.

Conditions

  • Diabetes Mellitus Type 1
  • Diabetic Maculopathy

Interventions

OTHER

COX inhibitor

Administration of 1 drop voltaren 45 minutes before recordings of diameter changes of retinal vessels are initiated

OTHER

L-NG-monomethyl arginine citrate

Intravenous administration of L-NMMA during recordings of diameter changes of retinal vessels

OTHER

COX inhibitor + L-NG-monomethyl arginine citrate

Combination of interventions. Administration of an eye drop voltaren and 45 minutes later infusion with L-NMMA is started and recording of diameter changes of retinal vessels is performed

Sponsors & Collaborators

  • University of Aarhus

    lead OTHER

Principal Investigators

  • Line Pedersen, MD · Aarhus University Hospital

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
20 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2012-11-30
Primary Completion
2016-03-31
Completion
2016-03-31

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01689090 on ClinicalTrials.gov