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The Utility of Multiplex PCR for Detection of DNA in Neutropenic Patients With Hematological Malignancies

NCT01669005 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 84

Last updated 2012-08-20

No results posted yet for this study

Summary

Objectives: Invasive infections are the leading cause of morbidity and mortality in patients treated for hematological malignancies. Blood cultures are often negative in neutropenic patients because of low-burden of organisms, previous antibiotic therapy or non-infectious reason of fever. More rapid, accurate and sensitive diagnostic tools are needed.

Hypothesis: Multiplex real-time PCR may detect microbial DNA in neutropenic patients before febrile episode. To investigate this hypothesis, EDTA-blood was routinely collected for multiplex PCR at admission and 3x/week thereafter until discharge or recovery from neutropenia

Conditions

Sponsors & Collaborators

  • University Hospital, Basel, Switzerland

    collaborator OTHER

  • Centre Hospitalier Universitaire Vaudois

    lead OTHER

Principal Investigators

  • Andrej Trampuz, MD · University Hospital Lausanne, Switzerland

  • Christina Orasch, MD · University Hospital Lausanne, Switzerland

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2007-11-30
Primary Completion
2008-12-31
Completion
2008-12-31

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Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01669005 on ClinicalTrials.gov