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Antioxidants for Prevention of Cataracts Follow-up Study

NCT01664819 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 576

Last updated 2018-10-30

No results posted yet for this study

Summary

Aravind Eye Hospital and the University of California, San Francisco (UCSF) Proctor Foundation collaborated on the Antioxidants for the Prevention of Cataract Study from 1997-2002. (1) In the study, 798 participants aged 35-50 years were enrolled from 5 rural villages, and randomized to thrice weekly antioxidants (vitamin C, 500 mg; beta carotene, 15 mg; and alpha-tocopherol, 400 IU) or placebo. After 5 years of supplementation, there was no significant difference in cataract formation between the antioxidant group and placebo. In this follow-up study, we will return to study villages to determine whether rates of cataract surgery are different in the 2 groups.

1\. Gritz DC, Srinivasan M, Smith SD, et al. The Antioxidants in Prevention of Cataracts Study: effects of antioxidant supplements on cataract progression in South India. The British journal of ophthalmology 2006;90:847-51.

Conditions

  • Cataract

Interventions

DIETARY_SUPPLEMENT

Antioxidant

DIETARY_SUPPLEMENT

Placebo

Sponsors & Collaborators

Principal Investigators

  • Jeremy D Keenan, MD, MPH · University of California, San Francisco

  • Muthiah Srinivasan, MD · Aravind Eye Hospitals

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
50 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2012-08-31
Primary Completion
2013-08-31
Completion
2013-08-31

Countries

  • India

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01664819 on ClinicalTrials.gov