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Effects of Topiramate on Adolescent Alcohol Use: Efficacy and Mechanisms

NCT01641445 · Status: COMPLETED · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 82

Last updated 2020-10-20

Study results available
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Summary

This study will help to determine whether the medication, topiramate, reduces alcohol use among adolescents with alcohol dependence. It will also help answer the question, "How does topiramate reduce drinking in teenagers?" Understanding how topiramate may reduce drinking in adolescents would allow for a more targeted pharmacotherapeutic approach to treatment and help to identify additional medications that may hold promise for improving treatment outcomes for youth.

Conditions

  • Alcohol Drinking

Interventions

DRUG

Topiramate

Topiramate (200 mg daily)

DRUG

Placebo

Matching placebo capusules ("sugar pills"

Sponsors & Collaborators

  • Brown University

    lead OTHER

Principal Investigators

  • Robert Miranda, Ph.D. · Brown University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
14 Years
Max Age
24 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2012-07-31
Primary Completion
2016-05-31
Completion
2017-04-12

Countries

  • United States

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01641445 on ClinicalTrials.gov