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Aspergillus-specific PCR Assay in Cerebrospinal Fluid Samples for Detection of Central Nervous System Aspergillosis

NCT01617759 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 200

Last updated 2020-04-20

No results posted yet for this study

Summary

Central nervous system (CNS) invasive aspergillosis (IA) is a fatal complication in immunocompromised patients. Confirming the diagnosis is rarely accomplished as invasive procedures are hampered by neutropenia and low platelet count. Cerebrospinal fluid (CSF) cultures or galactomannan (GM) regularly yield negative results thus suggesting the need for improving diagnostics. Therefore the performance of an established Aspergillus-specific nested PCR in CSF samples of immunocompromised patients with suspicion of CNS IA will be evaluated.

Conditions

  • Aspergillosis
  • Infection in an Immunocompromised Host

Sponsors & Collaborators

  • Heidelberg University

    lead OTHER

Principal Investigators

  • Dieter Buchheidt, MD · Mannheim University Hospital, University of Heidelberg, Germany

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2007-09-30
Primary Completion
2020-12-31
Completion
2020-12-31

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01617759 on ClinicalTrials.gov