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Studies of Disorders With Increased Susceptibility to Fungal Infections

NCT01222741 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 850

Last updated 2026-05-22

No results posted yet for this study

Summary

Background:

\- Researchers are interested in studying disorders that make individuals more susceptible to fungal infections, specifically infections with the Candida yeast. These disorders are often related to problems with the immune system and may have genetic factors, which suggests that researchers should study not only the individual with the disorder, but also his or her first- and second-degree relatives (such as parents, siblings, children, and first cousins). To provide material for future research, individuals with immune disorders and their first- and second-degree relatives will be asked to provide blood and other samples for testing and comparison with samples taken from healthy volunteers with no history of immune disorders.

Objectives:

\- To collect blood and other biological samples to study immune disorders that make individuals more susceptible to fungal infections.

Eligibility:

* Individuals of any age who have abnormal immune function characterized by recurrent or unusual fungal infections, recurrent or chronic inflammation, or other types of immune dysfunction.
* First- or second-degree genetically related family members (limited to mother, father, siblings, grandparents, children, aunts, uncles, and first cousins).
* Healthy volunteers at least 18 years of age (for comparison purposes).

Design:

* Participants will provide blood samples and buccal (cells from the inside of the mouth near the cheek) samples.
* Participants with immune disorders will also be asked to provide urine samples, saliva or mucosal samples, or skin tissue biopsies, and may also have imaging studies (such as x-rays) to collect information for research.
* Samples may be collected at the National Institutes of Health or at other clinical locations for the samples to the sent to the National Institutes of Health.
* No treatment will be provided as part of this protocol....

Conditions

  • Fungal Infections
  • Primary Immune Deficiencies

Sponsors & Collaborators

  • National Institute of Allergy and Infectious Diseases (NIAID)

    lead NIH

Principal Investigators

  • Sergio D Rosenzweig, M.D. · National Institute of Allergy and Infectious Diseases (NIAID)

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2011-01-07

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01222741 on ClinicalTrials.gov