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Unraveling the Nature of Impaired Pain Inhibition in Patients With Chronic Whiplash-associated Disorders

NCT01601912 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 59

Last updated 2014-01-14

No results posted yet for this study

Summary

The primary study aim is to unravel the nature of impaired pain inhibition during exercise in patients with chronic Whiplash-Associated Disorders (WAD). This will be ascertained by examining whether activation of serotonergic and/or noradrenergic descending pathways improves pain inhibition during exercise in these patients. In addition, it is aimed at examining whether activation of serotonergic and/or noradrenergic descending pathways prevents post-exertional malaise following submaximal exercise in chronic WAD patients. A secondary study aim comprises of examining the effect of an acute submaximal exercise with and without activation of serotonergic or noradrenergic descending pathways on chronic WAD patients' cognitive performance. Furthermore, the isolated effect of activated serotonergic and noradrenergic descending pathways on chronic WAD patients' cognitive performance will be studied.

Conditions

  • Whiplash Injuries

Interventions

DRUG

Atomoxetine

40 mg, 1 application

DRUG

Citalopram

20 mg, 1 application

Sponsors & Collaborators

  • Vrije Universiteit Brussel

    lead OTHER

Principal Investigators

  • Jo Nijs, PhD · Vrije Universiteit Brussel

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-02-28
Primary Completion
2013-12-31
Completion
2013-12-31

Countries

  • Belgium

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01601912 on ClinicalTrials.gov