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Effect of Repeated Doses of YF476 on Stomach Acidity

NCT01601405 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 10

Last updated 2012-05-18

No results posted yet for this study

Summary

The objectives of the study were:

1. To show that a single dose of YF476 blocks gastrin receptors in healthy subjects
2. To show that YF476 retains its ability to block gastrin receptors after repeated dosing despite losing its ability to suppress gastric acidity.

Conditions

  • Hypergastrinaemia

Interventions

DRUG

YF476

Each subject took one capsule of YF476 100 mg twice daily on Days 1-6 and once on Day 7. Each capsule taken with water 150 mL.

DRUG

Placebo

On Days 0 and 14, each subject took a placebo capsule. Each capsule taken with water 150 mL.

Sponsors & Collaborators

  • James Black Foundation

    collaborator UNKNOWN

  • Trio Medicines Ltd.

    lead INDUSTRY

Principal Investigators

  • Malcolm Boyce · Trio Medicines Limited

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2001-10-31
Primary Completion
2001-11-30
Completion
2001-11-30

Countries

  • United Kingdom

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01601405 on ClinicalTrials.gov