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Role of Polymorphisms in the Dectin-1 Gene in Determining the Risk of Candida Colonization and Infection in Critically Ill Patients

NCT01482988 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 600

Last updated 2011-12-01

No results posted yet for this study

Summary

The principal aim of this study is to establish if a polymorphism in a gene important for innate immunity to fungi represents a significant risk factor for the development of Candida colonisation and subsequent invasive candidosis in critically ill patients. Incorporation of a screening programme onto a risk-based algorithm for critical care patients would allow more effective targeting of molecular diagnostic tests, anti-fungal prophylaxis and targeted treatment. Sequential critical care patients will be screened for gene polymorphisms and undergo regular screening for Candida colonization.

Conditions

  • Critically Ill

Sponsors & Collaborators

  • Cardiff University

    collaborator OTHER

  • Cardiff and Vale University Health Board

    lead OTHER_GOV

Principal Investigators

  • Rosemary Barnes · Cardiff University

  • Matt P Wise · Cardiff and Vale Local Health Board

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2011-12-31

Countries

  • United Kingdom

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01482988 on ClinicalTrials.gov