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Hypodontia and Ovarian Cancer

NCT01470235 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 200

Last updated 2013-11-01

No results posted yet for this study

Summary

The purpose of this project is to examine whether the risk of developing ovarian cancer is increased in Danish women with congenital missing teeth as a result of their failure to develop (hypodontia). Should this prove to be the case, these women could be offered regular clinical controls and prophylactic removal of their ovaries when menopause enters and the ovaries are no longer functional (producing hormones).

If there is a connection between congenital hypodontia and the development of different types of cancer, the investigators will perform a genetic screening in families with increased risk of cancer and hypodontia for changes in relevant genes, based on the current literature. The investigators hereby search for new genes, which in a changed form leads to an increased risk of cancer and thereby enables us to perform genetic screening in risk families.

Conditions

Sponsors & Collaborators

  • Danish Cancer Society

    collaborator OTHER

  • Arvid-Nilsson Foundation

    collaborator UNKNOWN

  • University of Aarhus

    lead OTHER

Principal Investigators

  • Jan Blaakaer, Professor, MD, DMSc · Aarhus University Hospital

  • Maria Cathrine C. V. Schmidt, MD, Ph.d.-student · Aarhus University Hospital

  • Charlotte Soegaard, MD, ph.d. · Aarhus University Hospital

  • Lone Sunde, Associate Professor, PhD · Aarhus University Hospital

  • Claus Hoegdall, Professor · Copenhagen University Hospital at Herlev

  • Michala O. Lexner, Dentist, PhD

Eligibility

Min Age
18 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2011-09-30
Primary Completion
2014-09-30
Completion
2015-08-31

Countries

  • Denmark

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01470235 on ClinicalTrials.gov