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Psychopathological Risk Factors Associated With Conversion From Mild Cognitive Impairment to Dementia

NCT01436552 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 392

Last updated 2011-09-19

No results posted yet for this study

Summary

Background: Dementias (Alzheimer's disease and related syndromes), in their sporadic form, have multifactorial origin. Several risk factors (RF) are currently recognized like the cardiovascular RF, some genes of susceptibility, but the impact \[1\] of traumatic life events (TLE), considered as psychosocial RF (Persson \& Skoog, 1996; Charles et al, 2006), \[2\] of anxiety and/or depression, \[3\] of the premorbid personality (Clément et al, 2003) with his coping strategies, and \[4\] of the lifestyle (which results from the personality), for the moment are still underestimated. Dementia disease can be clinically preceded by a mild cognitive impairment (MCI) (Petersen et al, 1996) which is however potentially reversible.

Purpose: Actually, there is no study concerning the rate of conversion from MCI to dementia according to the presence or not of TLE. The aim of this study is to assess association between TLE and conversion rate from MCI to dementia.

Methods: Patients with MCI will be recruited in different memory clinics (Limoges and others) Primary outcome: Occurrence of dementia according to DSM-IV-TR criteria in MCI patients according to their cumulated score of TLE measured by EVVIE.

Secondary outcomes: Occurrence of dementia in MCI patients according to various other psychopathological factors: anxiety, depression, apathy, personality features, alexithymia and resilience levels and life style.

Study design: Epidemiologic cohort longitudinal and prospective multicenter study.

Conditions

Sponsors & Collaborators

  • Centre Hospitalier Esquirol

    lead OTHER

Principal Investigators

  • Jean-Pierre Clement, MD, PhD · CH Esquirol

Eligibility

Min Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2010-02-28
Primary Completion
2012-02-29
Completion
2014-02-28

Countries

  • France

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01436552 on ClinicalTrials.gov