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A Study to Assess the Levels of Two Antibiotics in the Blood When Given Together and Separately

NCT01430910 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 43

Last updated 2017-09-01

No results posted yet for this study

Summary

This is a randomised study divided into 2 parts. Part A investigates the effect of prolonged dosing (ten days) with Avibactam and Ceftazidime when given together and how this will effect how much Avibactam and Ceftazidime enters the blood. Part B investigates how much Avibactam (NXL104) and Ceftazidime enter the blood when Avibactam and Ceftazidine are given separately or together intravenously.

Conditions

  • Healthy

Interventions

DRUG

CAZ104

IV infusion

DRUG

Avibactam

IV infusion

DRUG

Ceftazidime

IV infusion

Sponsors & Collaborators

Principal Investigators

  • Mirjana Kujacic, MD · AstraZeneca Research and DevelopmentSE-431 83 Mölndal Sweden

  • Leonard Siew, MBCHB · Quintiles Drug Research Unit at Guy's Hospital 6 Newcomen St London SE1 1YR United Kingdom

  • Paul Newell, MD · AstraZeneca R&D Alderly Park, Mereside SK 104 TG Macclesfield, Cheshire United Kingdom

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2011-09-30
Primary Completion
2012-10-31
Completion
2012-10-31

Countries

  • United Kingdom

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01430910 on ClinicalTrials.gov