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Analysis of Human Coronary Aspirate

NCT01430884 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 500

Last updated 2014-12-03

No results posted yet for this study

Summary

During elective percutaneous coronary intervention (PCI), both proximal and distal protection devices are used. The distal occlusion protection device temporarily occludes the vessel distal to the lesion during the intervention, thereby capturing both particular debris and soluble substances released from the lesion such that they can be aspirated and prevented from reaching the coronary microcirculation. Rather than simply discarding the material which is retrieved from use of protection devices, the investigators have recently taken advantage of this situation, sampled the particulate and soluble material and subjected it to a variety of analyses with the ultimate goal to have a better insight into the respective plaque composition and to correlate it to the individual imaging and clinical data. On the basis of such information the investigators aim to better understand the pathophysiology of plaque vulnerability and to possibly predict the clinical development of the individual patient.

Conditions

Interventions

OTHER

Aspirated Coronary Blood

Coronary arterial blood is taken distal to the lesion before stent implantation and serve as control and coronary aspirate blood is obtained during stent implantation.

Sponsors & Collaborators

  • Universität Duisburg-Essen

    lead OTHER

Principal Investigators

  • Petra Kleinbongard, PhD · Institute of Pathophysiology, University of Essen Medical School

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2004-04-30
Primary Completion
2015-03-31
Completion
2015-11-30

Countries

  • Germany

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01430884 on ClinicalTrials.gov