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TLR-9 Antagonism in Steroid Resistant Optic Neuritis

NCT01424735 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 8

Last updated 2011-08-29

No results posted yet for this study

Summary

Although idiopathic steroid resistant optic neuritis is very uncommon, there is no established treatment protocol for such patients. Toll like receptors (TLRs) especially TLR-9 has been shown to play a role in the pathogenesis of optic neuritis. This small case series aims to determine whether immunomodulators directed specifically at TLR-9(i.e. TLR-9 antagonism)play any role in improving the visual function in such patients.

Conditions

Interventions

DRUG

Mycobacterium w.(Mw)-freeze dried extract 0.5ml

0.5 ml of Mw in 500ml 0.9% normal saline administered over two hours as an infusion. 2ml(4mg/ml) of dexamethasone administered two hours prior to Mw administration

Sponsors & Collaborators

  • Sudhalkar Eye Hospital

    lead OTHER

Principal Investigators

  • Bakulesh M Khamar, M.S. Ophthalmology · Thakore Eye Hospital, Ahmedabad

  • Mayuri B Khamar, M.S.Ophthalmology · M & J Institute Of Ophthalmology

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2006-07-31
Primary Completion
2010-01-31
Completion
2010-05-31

Countries

  • India

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01424735 on ClinicalTrials.gov