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Moringa Oleifera- Antiretroviral Pharmacokinetic Drug Interaction

NCT01410058 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 19

Last updated 2019-04-02

Study results available
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Summary

A study will be conducted by scientists from the University of Zimbabwe to determine if antiretroviral drugs are affected by taking herbs at the same time. This is important because herbal medicines may interact with modern medicine to increase or decrease the amount of medication in the body.

The drugs nevirapine and efavirenz will be studied. Both drugs are routinely used as part of combination therapy for treating HIV. In this study it will be determined whether the concentrations of the antiretroviral drugs nevirapine and efavirenz are low, high or are in the desired range when taken together with the herb moringa.

Conditions

Interventions

DIETARY_SUPPLEMENT

Moringa oleifera

leaf powder, 1.85g once daily, hard gelatin capsules

DRUG

Efavirenz 600mg

Efavirenz 600mg based regimen

DRUG

Nevirapine 200Mg Oral Tablet

Nevirapine 200mg based regimen

Sponsors & Collaborators

  • State University of New York at Buffalo

    collaborator OTHER

  • Biomedical Research and Training Institute

    collaborator OTHER

  • University of Zimbabwe

    lead OTHER

Principal Investigators

  • Tsitsi G Monera, BPharmHons, MPhil, MSc CT · University of Zimbabwe

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-01-31
Primary Completion
2013-09-30
Completion
2013-09-30

Countries

  • Zimbabwe

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01410058 on ClinicalTrials.gov