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Assessment of Liver Glucose Metabolism in Diabetic Subjects

NCT01397279 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 22

Last updated 2023-06-05

No results posted yet for this study

Summary

Type 2 diabetes is associated with hepatic insulin resistance. One consequence of insulin resistance of the liver is an altered hepatic glucose metabolism. This study investigates whether the whole body (M-value) and hepatic insulin sensitivity obtained by hyperinsulinemic euglycemic clamp is influenced by a preceding intravenous glucose tolerance test (Botnia Clamp) in subjects with type 2 diabetes.

Conditions

  • Newly Diagnosed Type 2 Diabetes (During the Last 12 Months)

Interventions

BIOLOGICAL

intravenous glucose tolerance test

Administration of a 30% weight-adapted glucose bolus intravenously.

BIOLOGICAL

hyperinsulinemic euglycemic clamp

Intravenous administration of 20% glucose and insulin over 3 hours

Sponsors & Collaborators

  • German Diabetes Center

    lead OTHER

Principal Investigators

  • Michael Roden, Prof., MD · Director German Diabetes Center

  • Michael Roden, Prof., MD · Director German Diabetes Center

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
35 Years
Max Age
69 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2011-07-31
Primary Completion
2013-12-31
Completion
2013-12-31

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01397279 on ClinicalTrials.gov