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The Effect of Losartan in Bicuspid Aortic Valve Patients

NCT01390181 · Status: TERMINATED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 4

Last updated 2017-04-14

Study results available
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Summary

The specific aims of this study are to:

* Establish baseline levels of circulating MMP-2 and -9 , TIMP-1and- 2 and TGFB levels in individuals with bicuspid aortic valve and ascending aortic or aortic sinus measurements \>40mm.
* Assess the effect on MMP levels during treatment with losartan, an angiotensin II receptor blocking agent.
* In the setting of losartan therapy for one year, evaluate the response of MMP levels in these patients, and clinical outcomes including effects on aortic growth rate

Conditions

  • Bicuspid Aortic Valve
  • Thoracic Aortic Aneurysm

Interventions

DRUG

Cozaar

Angiotensin II Receptor Blocker

Sponsors & Collaborators

Principal Investigators

  • Anna Booher, MD · University of Michigan

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2011-09-30
Primary Completion
2014-01-31
Completion
2014-01-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01390181 on ClinicalTrials.gov